- Louisa Giles
Birth - 1821 - West Virginia - Charity Baynes
Birth - 1821 - Smithland, Livingston, Kentucky - Elizabeth Griffin
Death - 1821 - Anderson, Anderson, South Carolina, USA - William Oliver "Bill" Pickens
Birth - 1821 - Harrison, Ohio - Susan Pickens
Birth - 1821 - Obion, Tennessee - Joseph Davidson Pickens
Death - 1821 - Cumberland, Pennsylvania - Archibald Thomas Peery
Birth - 1821 - Cumberland, Harlan, Kentucky, USA - Sion Record Pickens
Birth - 1821 - Hardin, Henderson, Tennessee, USA - Harris Pickens
- Matilda Caroline Patton
- David Reed Shannon
- James Pickens
- John Finus Pickens
- William Alexander Pickens
- Laurence "Larry" Shine
- Samuel W. Pickens Sr
Death - 9 June 1821 - Cabarrus, Cabarrus, North Carolina, USA - John Pickens
- Isabella Pickens
- James Kirkland
- Phebe Jane Crecelius
Birth - 18 July 1821 - New Amsterdam, Harrison, Indiana, USA - Malena Brown
- Andrew "Eighteen Mile" Pickens
- Margaret Nelan
- Cynthia Belcher
- Rebecca Calhoun Noble
- Andrew Martin Black
- David Randall Pickens
- James Pickens III
- James David Belcher
- Barbara Straw
- John E. "Pink" Hise
- Suzannah Pickens
- James Belcher
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