- Louisa Giles
 Birth - 1821 - West Virginia - Joseph Davidson Pickens
 Death - 1821 - Cumberland, Pennsylvania - Susan Pickens
 Birth - 1821 - Obion, Tennessee - William Oliver "Bill" Pickens
 Birth - 1821 - Harrison, Ohio - Elizabeth Griffin
 Death - 1821 - Anderson, Anderson, South Carolina, USA - Charity Baynes
 Birth - 1821 - Smithland, Livingston, Kentucky - Thomas Jefferson Pickens
 Birth - 1821 - Maury, Obion, Tennessee, USA - Archibald Thomas Peery
 Birth - 1821 - Cumberland, Harlan, Kentucky, USA - Sion Record Pickens
 Birth - 1821 - Hardin, Henderson, Tennessee, USA - Harris Pickens
 - David Reed Shannon
 - Matilda Caroline Patton
 - James Pickens
 - John Finus Pickens
 - William Alexander Pickens
 - Laurence "Larry" Shine
 - Samuel W. Pickens Sr
 Death - 9 June 1821 - Cabarrus, Cabarrus, North Carolina, USA - John Pickens
 - Isabella Pickens
 - James Kirkland
 - Phebe Jane Crecelius
 Birth - 18 July 1821 - New Amsterdam, Harrison, Indiana, USA - Andrew "Eighteen Mile" Pickens
 - Margaret Nelan
 - Cynthia Belcher
 - Rebecca Calhoun Noble
 - Andrew Martin Black
 - David Randall Pickens
 - James Pickens III
 - James David Belcher
 - Barbara Straw
 - John E. "Pink" Hise
 - Suzannah Pickens
 - James Belcher

| |